منابع مشابه
Organelle acidification and disease.
A subset of cellular compartments maintain acidic interior environments that are critical for the specific functions of each organelle and for cell growth and survival in general. The pH of each organelle reflects the balance between proton pumping, counterion conductance, and proton leak. Alterations in steady-state organelle pH due to defects in either proton pumping activity or counterion co...
متن کاملOrganelle acidification negatively regulates vacuole membrane fusion in vivo
The V-ATPase is a proton pump consisting of a membrane-integral V0 sector and a peripheral V1 sector, which carries the ATPase activity. In vitro studies of yeast vacuole fusion and evidence from worms, flies, zebrafish and mice suggested that V0 interacts with the SNARE machinery for membrane fusion, that it promotes the induction of hemifusion and that this activity requires physical presence...
متن کاملThe where, when, and how of organelle acidification by the yeast vacuolar H+-ATPase.
All eukaryotic cells contain multiple acidic organelles, and V-ATPases are central players in organelle acidification. Not only is the structure of V-ATPases highly conserved among eukaryotes, but there are also many regulatory mechanisms that are similar between fungi and higher eukaryotes. These mechanisms allow cells both to regulate the pHs of different compartments and to respond to changi...
متن کاملIntracellular ClC-3 chloride channels promote bone resorption in vitro through organelle acidification in mouse osteoclasts.
ClC-7 Cl(-) channels expressed in osteoclasts are important for bone resorption since it has been shown that disruption of the ClCN7 gene in mice leads to severe osteopetrosis. We have previously reported that Cl(-) currents recorded from mouse osteoclasts resemble those of ClC-3 Cl(-) channels. The aim of the present study was to determine the expression of ClC-3 channels in mouse osteoclasts ...
متن کاملMitochondria: Key Organelle in Parkinson's Disease
1Department of Cell Biology, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, 9713 AV Groningen, Netherlands 2Equipe 11 Labellisee par la Ligue Nationale contre le Cancer, Center de Recherche des Cordeliers, 75006 Paris, France 3INSERM, U1138, 75006 Paris, France 4Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France 5Université Pierre et Ma...
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ژورنال
عنوان ژورنال: Traffic
سال: 2003
ISSN: 1398-9219
DOI: 10.1034/j.1600-0854.2003.40201.x